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The Rapid Microdialyzer -- developed by Pacific Northwest National Laboratory -- moves biological microsamples from dialysis to analysis in less than four minutes. The sample enters an ion-permeable dialysis tube and flows toward the electrospray interface. A countercurrent flow of buffer solution surrounds the dialysis tube. Salt ions in the sample exchange places with ammonium ions in the buffer. The cleaned sample is electrosprayed into the mass spectrometer for analysis.

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Document Title: Rapid Microdialyzer
Category: Health-Related Research and Technologies
Media Type: Photos
Date of Image/Photo: February 1998
Background: Biological samples naturally contain high concentrations of salts and other compounds, which can create problems during analysis. The Rapid Microdialyzer quickly removes the salts and cleans samples, including microsamples that otherwise might not be usable. The Rapid Microdialyzer is expected to expand significantly medical, clinical, and analytical applications of mass spectrometry. The Rapid Microdialyzer won a 1998 R&D 100 Award.
URL of this page: http://picturethis.pnl.gov/picturet.nsf/by+id/SMAA-3XKPS4

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